Tropical spastic paraparesis (TSP) and other chronic-progressive myelopathies have been clearly associated with increased serum and cerebrospinal fluid antibody titers to human T-lymphotropic virus type I (HTLV-I). However, little is known about the cellular immune function in TSP. In the present st
Tropical spastic paraparesis: Clinical, immunological, and virological studies in two patients from martinique
✍ Scribed by Dr. Marinos C. Dalakas; Gary Stone; Gregory Elder; Mauro Ceroni; David Madden; Gustavo Román; John L. Sever
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 630 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0364-5134
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## Abstract There is no effective therapy for human T‐cell lymphotropic virus type I (HTLV‐I)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP). Glucocorticoids are effective to reduce the motor disability in these patients, but its role as anti‐spastic drugs is unknown. Here it is repor
## Abstract Human T‐lymphotropic virus 1 (HTLV‐1) infection is associated with HTLV‐associated myelopathy/tropical spastic paraparesis (HAM/TSP), which affects approximately 5% of carriers. High proviral load is a risk marker for HAM/TSP, although there is an overlap of proviral load levels in peri