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A chiral intermediate for thienamycin analogue synthesis: (3S,4R)-4-(2-hydroxyethyl)-3-[(R)-1-(4-nitrobenzyloxycarbonyloxy)etryl]azetidin-2-one

✍ Scribed by Terence C. Smale


Book ID
104233693
Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
123 KB
Volume
25
Category
Article
ISSN
0040-4039

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✦ Synopsis


Incorporation of a chiral ketone into the established tetrahydro-1,3-oxazine route to thienamycin analogues, has enabled the isolation of single enantiomers having the naturally occurring (&)-configuration at the bridgehead.


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