Through the synthesis of authentic samples, we have now determined that the major by-product arising from the conversion 4?5 is the PMB ether of m-bromophenol (A) and not the PMB ether of the corresponding o-isomer (B) as originally stated.
✦ LIBER ✦
A chemoenzymatic synthesis of the anti-influenza agent Tamiflu®
✍ Scribed by Maria Matveenko; Anthony C. Willis; Martin G. Banwell
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 284 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
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Annual epidemics of influenza virus infection are responsible for considerable morbidity and mortality, and pandemics are much more devastating. Considerable knowledge of viral infectivity and replication has been acquired, but many details still have to be elucidated and the virus remains a challen