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A Chemoenzymatic Synthesis of Carbocyclic Nucleosides and Nucleotides

✍ Scribed by Miriam Mahler; Bastian Reichardt; Jan Balzarini; Chris Meier


Book ID
113458345
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
67 KB
Volume
86
Category
Article
ISSN
0166-3542

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Synthesis of difluorocyclopropyl carbocy
✍ RenΓ© Csuk; Leo Eversmann πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 948 KB

Racemic difluorinated carbocyclic homo-nucleoside analogues are easily accessible from (Z)-4-(benzyloxy)-2-butenyl acetate by difluorocyclopropanation using sodium chlorodifluoro acetate in diglyme at 190Β°C followed by Mitsunobu reactions.