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Synthesis of difluorocyclopropyl carbocyclic homo-nucleosides

✍ Scribed by René Csuk; Leo Eversmann

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
948 KB
Volume
54
Category
Article
ISSN
0040-4020

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✦ Synopsis

Racemic difluorinated carbocyclic homo-nucleoside analogues are easily accessible from (Z)-4-(benzyloxy)-2-butenyl acetate by difluorocyclopropanation using sodium chlorodifluoro acetate in diglyme at 190°C followed by Mitsunobu reactions.

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