A chemoenzymatic approach towards moenomycin structural analogues

✍ Scribed by Gerhard Range; Ralf Krähmer; Peter Welzel; Dietrich Müller; Guido F. Herrmann; Udo Kragl; Christian Wandrey; Astrid Markus; Yveline van Heijenoort; Jean van Heijenoort

• Book ID: 104207478
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 862 KB
• Volume: 53
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(96)01116-7

✦ Synopsis

The trisaccharide moenomycin analogue lc has been synthesized. One starting material was N-acetyllactosamine obtained by an enzyme-catalyzed transglycosylation. lc differs from moenomycin degradation product la only in two positions of unit C In contrast to la the synthetic lc is antibiotically inactive.