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A chemical model for the thymidylate synthetase catalysed methylation of deoxyuridine monophosphate

✍ Scribed by Charlton, Peter A.; Young, Douglas W.


Book ID
118007955
Publisher
Royal Society of Chemistry
Year
1982
Weight
891 KB
Category
Article
ISSN
1472-7781

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The NMR study of the reaction of methylparathion with thiol (glutathione) and a tertiary amine shows nnambiguously a sequential transfer of the methyl group firstly to the amine and secondly to the thiol. The reaction stops after a single demethylation. This observation may account for regiospecific