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A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases

✍ Scribed by Wiesner, Silke; Wybenga-Groot, Leanne E; Warner, Neil; Lin, Hong; Pawson, Tony; Forman-Kay, Julie D; Sicheri, Frank

Book ID
118676749
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
515 KB
Volume
25
Category
Article
ISSN
0261-4189

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## Abstract Ephrins and Eph receptors are a family of molecules that have been implicated in axonal pathfinding. A unique feature of B‐class ephrins and Eph receptors is their ability to transmit bidirectional signals in both ephrin‐ and Eph receptor‐expressing cells upon cell–cell contact. These s