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A cell-based screen for inhibitors of protein folding and degradation

โœ Scribed by Frank Boschelli; Jennifer M. Golas; Roseann Petersen; Vincent Lau; Lei Chen; Diane Tkach; Qiang Zhao; Dave S. Fruhling; Hao Liu; Chaneun Nam; Kim T. Arndt


Book ID
107620333
Publisher
Springer Netherlands
Year
2010
Tongue
English
Weight
518 KB
Volume
15
Category
Article
ISSN
1355-8145

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โœ Brian S. J. Blagg; Timothy D. Kerr ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 793 KB

## Abstract The 90 kDa heat shock proteins (Hsp90) are responsible for the conformational maturation of nascent polypeptides and the renaturation of denatured proteins. In transformed cells, numerous mutated and overexpressed proteins rely on the Hsp90 protein folding machinery for tumor progressio