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Hsp90 Inhibitors: Small Molecules that Transform the Hsp90 Protein Folding Machinery into a Catalyst for Protein Degradation.

✍ Scribed by Brian S. J. Blagg; Timothy D. Kerr

Publisher: John Wiley and Sons
Year: 2006
Weight: 8 KB
Volume: 37
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200632286

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✦ Synopsis

Abstract

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Hsp90 inhibitors: Small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation

✍ Brian S. J. Blagg; Timothy D. Kerr 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 793 KB

## Abstract The 90 kDa heat shock proteins (Hsp90) are responsible for the conformational maturation of nascent polypeptides and the renaturation of denatured proteins. In transformed cells, numerous mutated and overexpressed proteins rely on the Hsp90 protein folding machinery for tumor progressio