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A CD4 mimic as an HIV entry inhibitor: Pharmacokinetics

โœ Scribed by Hashimoto, Chie; Narumi, Tetsuo; Otsuki, Hiroyuki; Hirota, Yuki; Arai, Hiroshi; Yoshimura, Kazuhisa; Harada, Shigeyoshi; Ohashi, Nami; Nomura, Wataru; Miura, Tomoyuki; Igarashi, Tatsuhiko; Matsushita, Shuzo; Tamamura, Hirokazu

Book ID
121322674
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
687 KB
Volume
21
Category
Article
ISSN
0968-0896

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CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist
โœ Tetsuo Narumi; Chihiro Ochiai; Kazuhisa Yoshimura; Shigeyoshi Harada; Tomohiro T ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 755 KB

Small molecules behaving as CD4 mimics were previously reported as HIV-1 entry inhibitors that block the gp120-CD4 interaction and induce a conformational change in gp120, exposing its co-receptor-binding site. A structure-activity relationship (SAR) study of a series of CD4 mimic analogs was conduc