A Catalytic Enantioselective Aza-Michael Reaction: Novel Protocols for Asymmetric Synthesis of β-Amino Carbonyl Compounds
✍ Scribed by Li-Wen Xu; Chun-Gu Xia
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 169 KB
- Volume
- 2005
- Category
- Article
- ISSN
- 1434-193X
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📜 SIMILAR VOLUMES
## Abstract The highly enantioselective organocatalytic domino aza‐Michael/aldol reaction is presented. The unprecedented, chiral amine‐catalyzed asymmetric domino reactions between 2‐aminobenzaldehydes and α,β‐unsaturated aldehydes proceed with excellent chemo‐ and enantioselectivity to give the c
## Abstract **Two activations are better than one**: The chiral bifunctional guanidine **1**, which features an amino amide backbone, catalyzes the asymmetric Michael addition of a range of substrates and gives products with excellent stereoselectivities. The method also allows the efficient synthe