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A Catalytic Asymmetric Method for the Synthesis of γ-Unsaturated β-Amino Acid Derivatives

✍ Scribed by Lurain, Alice E.; Walsh, Patrick J.


Book ID
126986676
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
146 KB
Volume
125
Category
Article
ISSN
0002-7863

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Catalytic asymmetric hydrogenation of β-
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The Rh-DuPHOS and Rh-BPE catalyzed hydrogenation of IS-substituted ¢x,[~,y,8-unsaturated amino acids establishes two contiguous stereogenic centers simultaneously. Both high regioselectivity and good to excellent enantioselectivity have been demonstrated in this process leading to I~-branched allyl