𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A Catalytic and Enantioselective Synthesis of trans-2-Amino-1- aryltetralins

✍ Scribed by Saumen Hajra; Biswajit Maji; Dipakranjan Mal

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
215 KB
Volume
351
Category
Article
ISSN
1615-4150

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

magnified image

The bis‐oxazoline‐copper complex‐catalyzed aziridination of alkenes followed by an intramolecular Friedel–Crafts alkylation of the tethered and in situ generated aziridine provides a one‐pot, general and efficient method for the synthesis of trans‐2‐amino__‐__1‐aryltetralins from a mixture of 2‐ arylethylstyrenes (E/Z≤85:15) with excellent dia‐ stereo‐ (dr>99:1) and enantioselectivities (up to 92% ee).

📜 SIMILAR VOLUMES

Corrigendum: A Catalytic and Enantiosele
Corrigendum: A Catalytic and Enantioselective Synthesis of trans-2-Amino-1- aryltetralins
✍ Saumen Hajra; Biswajit Maji; Dipakranjan Mal 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 66 KB 👁 1 views

the optical rotation ([a] D 25 ) of compound 6 should read +19.9 (c 1.0, CHCl 3 ) instead of À 19.9 (c 1.3, CHCl 3 ). Hence the absolute configurations of 2, 36, 6, 7 and 8 should correspond to those of the enantiomers. The authors apologize for this error. The corresponding corrections have been ma

Catalytic Concepts for the Enantioselect
Catalytic Concepts for the Enantioselective Synthesis of α-Amino and α-Hydroxy Phosphonates
✍ Harald Gröger; Benedikt Hammer 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 116 KB 👁 1 views

The enantioselective synthesis of a-aminoand a-hydroxy phosphonates by catalytic processes has attracted considerable interest in the last few years, not least because of the pharmaceutical interest in such compounds. This article contains a compilation of the asymmetric synthesis methods developed