Mast cell disease associated with acute
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Vinod A. Pullarkat; Sheeja T. Pullarkat; David C. Calverley; Russell K. Brynes
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Article
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2000
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John Wiley and Sons
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English
⚖ 68 KB
👁 2 views
Mast cell disease (MCD), a proliferation of mast cells (MC), is occasionally associated with hematologic malignancies. Neoplastic MC have activating c-kit mutations. c-kit is a receptor tyrosine kinase required for the development, proliferation, and survival of MC. Interaction of c-kit with its lig