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A case of ‘smouldering’ mastocytosis with high mast cell burden, monoclonal myeloid cells, and C-KIT mutation Asp-816-Val

✍ Scribed by John-Hendrik Jordan; Robert Fritsche-Polanz; Wolfgang R. Sperr; Gerlinde Mitterbauer; Manuela Födinger; Gerit-Holger Schernthaner; Hans Christian Bankl; Walter Gebhart; Andreas Chott; Klaus Lechner; Peter Valent


Book ID
114118984
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
221 KB
Volume
25
Category
Article
ISSN
0145-2126

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Mast cell disease (MCD), a proliferation of mast cells (MC), is occasionally associated with hematologic malignancies. Neoplastic MC have activating c-kit mutations. c-kit is a receptor tyrosine kinase required for the development, proliferation, and survival of MC. Interaction of c-kit with its lig