A case of HHV-8-associated HIV-negative primary effusion lymphoma in Moscow
✍ Scribed by D. Shirokov; E. Kadyrova; M. Anokhina; T. Kondratyeva; V. Gourtsevich; N. Tupitsyn
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 180 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0146-6615
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✦ Synopsis
Abstract
Primary effusion lymphoma is a rare tumor of B‐cell derivation which is associated with human herpes virus type 8 (HHV‐8) in 100% and with human immunodeficiency virus (HIV) in most of cases. The paper describes the first case in Russia of HIV^−^ HHV‐8^+^ Epstein–Barr virus (EBV)^+^ primary effusion lymphoma in a male patient aged 56 years. The tumor was located in the pleural cavity. Interestingly, the patient was HIV‐negative while having a positive tumor HHV‐8 test. There are only 22 similar cases described worldwide. J. Med. Virol. 79:270–277, 2007. © 2007 Wiley‐Liss, Inc.
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Primary lymphomatous effusions are represented by cases of non-Hodgkin's lymphoma (NHL) which grow in liquid phase in the serous body cavities in the absence of solid tumour masses. Based on morphologic, immunophenotypic, virologic and genotypic features, primary lymphomatous effusions are distingui
Primary effusion lymphoma (PEL) is a novel lymphoproliferative disorder associated with human herpesvirus 8 (HHV-8) infection. Most PELs develop in HIV-seropositive individuals and are nearly always positive for Epstein-Barr virus (EBV), a finding which obscures the role of HHV-8 in lymphomagenesis.
## Abstract Primary effusion lymphoma (PEL) is a rare KSHV/HHV8‐associated high‐grade non‐Hodgkin's lymphoma (NHL) of B‐cell origin, characterized by serous effusions in body cavities. Most patients are HIV‐infected homosexual men with severe immunosuppression and other KSHV/HHV8‐associated disease