✦ LIBER ✦

A case of atypical myelodysplastic syndrome with micromegakaryocytes, normal platelet count, and t(3;12)(q21;p13) with inv(3)(q21q26)

✍ Scribed by Susanne Schnittger; Claudia Schoch; Berthold Streubel; Hans-Fokke Hinrichs; Burkhardt Otremba; Raza Parwaresch; Christa Fonatsch

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 702 KB
Volume: 20
Category: Article
ISSN: 1045-2257
DOI: 10.1002/(sici)1098-2264(199711)20:3<292::aid-gcc10>3.0.co;2-r

No coin nor oath required. For personal study only.

✦ Synopsis

A 49-year-old woman patient with atypical myelodysplastic syndrome (MDS) showing a der(3)t(3;12)(q21;p13), and der(12)t(3; 12)(q21;p13)inv(3)(q21q26) as an acquired chromosomal abnormality in the bone marrow is described. The chromosomal breakpoints of the presented complex aberration with combination of the inv(3)(q21q26) and t(3;12)(q21;p13) were defined by fluorescence in situ hybridization (FISH) with yeast artificial chromosomes (YACs). The inv(3) is a relatively frequent chromosomal rearrangement in patients with myeloid malignancies and dysmegakaryopoiesis and t(3;12)(q26;p13) has also been reported as a recurrent abnormality in MDS and in blast crisis of chronic myelogenous leukemia (CML). Whereas the t(3;12), inv(3), and t(3;3) are associated with a very poor prognosis, our patient surprisingly had a mild clinical course.

📜 SIMILAR VOLUMES

Apparent duplication of inv(3)(q21q26) i

Apparent duplication of inv(3)(q21q26) in one of five cases with inv (3) in myelodysplastic syndromes and acute leukemia

✍ Thomas A. Walter; Rodman Morgan; Sharon Ondreyco; Dr. Avery A. Sandberg 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 453 KB

A case of myelodysplastic syndrome with

A case of myelodysplastic syndrome with erythroid hypoplasia associated with a familial translocation t(3;14)(p21.1;q24.1)

✍ Günçağ Dinçol; Şükrü Öztürk; Şükrü Palanduz; Gülçin Tutkan; Naciye Yıldırım; Mes 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB 👁 3 views

Clinical correlations of the 3q21;q26 cy

Clinical correlations of the 3q21;q26 cytogenetic anomaly. A leukemic or myelodysplastic syndrome with preserved or increased platelet production and lack of response to cytotoxic drug therapy

✍ Tomas Pintado; Maria Teresa Ferro; Carlos San Román; Magdalena Mayayo; Jose G. L 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 909 KB

Three patients presenting with acute leukemic disorder and chromosome 3 rearrangement involving bands q21;q26 are reported, and the literature on chromosome 3q abnormalities is reviewed. All reported patients carrying a paracentric 3q inversion or a translocation 3;3 with breakpoints in q21;q26 had

Acute myelogenous leukemia with the t(3;

Acute myelogenous leukemia with the t(3;12)(q26;p13) translocation: Case report and review of the literature

✍ Ioannis A. Voutsadakis; Natacha Maillard 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 44 KB 👁 1 views

Zimmermann-Laband syndrome associated wi

Zimmermann-Laband syndrome associated with a balanced reciprocal translocation t(3;8)(p21.2;q24.3) in mother and daughter: Molecular cytogenetic characterization of the breakpoint regions

✍ Stefanova, Margarita ;Atanassov, Dimitar ;Krastev, Tzaniu ;Fuchs, Sigrid ;Kutsch 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 277 KB 👁 3 views

PRENATAL AND POSTNATAL INVESTIGATION OF

PRENATAL AND POSTNATAL INVESTIGATION OF A CASE WITH MILLER–DIEKER SYNDROME DUE TO A FAMILIAL CRYPTIC TRANSLOCATION t(17;20) (p13.3;q13.3) DETECTED BY FLUORESCENCE IN SITU HYBRIDIZATION

✍ S. L. VAN ZELDEREN-BHOLA; E. J. BRESLAU-SIDERIUS; G. C. BEVERSTOCK; I. STOLTE-DI 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 415 KB 👁 3 views

We present here a case report of a fetus with a kidney anomaly and dilated occipital horns, detected initially by echoscopy at 29 weeks' amenorrhoea. After 31 weeks of gestation, the proband was born with clinical symptoms of Miller-Dieker syndrome. This was subsequently confirmed by fluorescence in