Clinical correlations of the 3q21;q26 cytogenetic anomaly. A leukemic or myelodysplastic syndrome with preserved or increased platelet production and lack of response to cytotoxic drug therapy
✍ Scribed by Tomas Pintado; Maria Teresa Ferro; Carlos San Román; Magdalena Mayayo; Jose G. Larana
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 909 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
Three patients presenting with acute leukemic disorder and chromosome 3 rearrangement involving bands q21;q26 are reported, and the literature on chromosome 3q abnormalities is reviewed. All reported patients carrying a paracentric 3q inversion or a translocation 3;3 with breakpoints in q21;q26 had a myelodysplastic or acute leukemic disorder with a normal or elevated platelet count and lack of response to cytotoxic drug therapy. They showed an associated incidence of -7 or 7q-anomalies higher than de now acute leukemia and appear to constitute a definite subgroup of the leukemic disorders with very poor prognosis. The majority of patients showing other chromosome 3 long arm rearrangements showed evidence of leukemic process, were in blastic crisis, or had been exposed to chemotherapy, exhibiting also a higher incidence of associated -5 or -7 cytogenetic abnormalities than is observed in patients not exposed to toxic agents.
Cancer 55535-541, 1985.
H E ASSOCIATION BETWEEN certain hematologic dis-
T orders and specific cytogenetic abnormalities has become firmly established and has acquired well-accepted diagnostic and prognostic value. Recently, several reports have linked chromosome 3 long arm defects and acute leukemia with thromb~cytosis.'-~ This report describes three patients with acute leukemia, a normal or near-normal platelet count, and structural abnormalities of chromosome 3 involving bands q21;q26, and reviews the literature on chromosome 3 long arm defects in hematologic disorders.
Case Reports
Patient I
A 25-year-old male police officer, was admitted on June 25, 198 1 because of progressive anemia and leucocyte count abnormalities. He complained of asthenia and anorexia of 1 year's duration, which had progressed during the preceding 2 months, with fever (373°C) and weight loss of 8 kg. On admission he appeared pale and emaciated. There was splenomegaly of 3 cm and he was febrile (383°C). The initial hematologic data are summarized in Table . The peripheral blood smear revealed striking morphologic abnormalities of the leucocytes and platelets with prominent pseudo-Pelger anomaly, giant neutrophils, and marked monocytoid features of the neutro-