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A case of acute myelogenous leukemia with MLL–AF10 fusion caused by insertion of 5′ MLL into 10p12, with concurrent 3′ MLL deletion

✍ Scribed by Kazuyuki Matsuda; Eiko Hidaka; Fumihiro Ishida; Kazuyoshi Yamauchi; Hideki Makishima; Toshiro Ito; Takefumi Suzuki; Eri Imagawa; Kenji Sano; Tsutomu Katsuyama; Hiroyoshi Ota


Book ID
113512997
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
414 KB
Volume
171
Category
Article
ISSN
0165-4608

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## Abstract The formation of a leukemogenic fusion product in hematopoietic malignancies is commonly achieved by chromosomal translocation. Alternate and cytogenetically undetectable mechanisms of fusion transcript generation have been documented for __BCR__–__AB1__, __AML1__–__ETO__, __PML__–__RAR