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A case of acute myelogenous leukemia: myelodysplastic syndrome with t(2;11)(p21;q23) without MLL rearrangement

โœ Scribed by Alessandro Gozzetti; Daniela Tozzuoli; Rosaria Crupi; Donatella Raspadori; Alberto Fabbri; Francesco Lauria

Book ID
114135593
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
51 KB
Volume
144
Category
Article
ISSN
0165-4608

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Identification of a novel fusion gene ML
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## Abstract We have identified a novel fusion partner of __MLL__, namely the mastermind like 2 (__MAML____2__ gene), in secondary acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) with inv(11)(q21q23). RTโ€PCR and sequencing revealed that exon 7 of __MLL__ was fused to exon 2 of __MAML

MLL is involved in a t(2;11)(p21;q23) in
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We describe a patient with acute myeloblastic leukemia (AML-M0) whose cells had a t(2;11)(p21;q23). Fluorescence in situ hybridization analysis with a probe for MLL showed that it was split, hybridizing to both the derivative 2 and 11 chromosomes. Nineteen other patients with 2p;11q translocations h