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A Cascade Cycloaddition Strategy Leading to the Total Synthesis of (−)-FR182877

✍ Scribed by David A. Evans; Jeremy T. Starr

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
110 KB
Volume
114
Category
Article
ISSN
0044-8249

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Total Synthesis of the Squalene Synthase
Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C by a Carbonyl Ylide Cycloaddition Strategy
✍ Seiichi Nakamura; Yuuki Hirata; Takahiro Kurosaki; Masahiro Anada; Osamu Kataoka 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB 👁 1 views

The zaragozic acids and squalestatins, a novel family of fungal metabolites isolated and characterized by researchers at Merck [1] and Glaxo, [2] respectively, in 1992, are the most potent inhibitors of squalene synthase known to date. [3] Some members of this family have also demonstrated the abili