A carbamoyl-protective group for tyrosine that facilitates purification of hydrophobic synthetic peptides
✍ Scribed by Karolina Wahlström; Ove Planstedt; Anders Undén
- Book ID
- 108284946
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 115 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Use of dimethylphosphinyl (Dmp) group as a side-chain phenolic OH protecting group of tyrosine in peptide synthesis was studied. The Dmp group is resistant to trifluoroacetic acid and hydrogenolysis and removed by fluoride ion or liquid HF. The formation of 3-benzyltyrosine from e-benzyl tyrosine in
The dipeptide Fmoc-Val-(2-hydroxy-4-methoxybenzyl)Gly-OBzl was synthesized and the 2-hydroxyl group carbamoylated to give a Boc-N(CH 3 )CH 2 CH 2 N(CH 3 )CO-, (Boc-Nmec-) modification of the 2-hydroxy-4-methoxybenzyl (Hmb) group. After catalytic hydrogenation and purification, the resulting dipeptid