A cannabinoid analogue of Δ9-tetrahydrocannabinol disrupts neural development in chick
✍ Scribed by Delphine Psychoyos; Basalingappa Hungund; Thomas Cooper; Richard H. Finnell
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 594 KB
- Volume
- 83
- Category
- Article
- ISSN
- 1542-9733
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The development of tolerance to delat9-tetrahydrocannabinol (delta9-THC) was examined. Rats with permanently indwelling intravenous catheters were injected daily with delta9-THC, 2 mg/kg, for up to 10 days and on each day subjective behaviour and body weight of each rat were noted. Tolerance appeare
## Abstract The routes leading to the formation of the most prominent fragment ion [C~15~H~19~O~2~]^+^ (__m/e__ 231) in the cannabinoid Δ^1(6)^ tetrahydrocannabinol were investigated with the aid of deuterium labelled compounds. A previously proposed mechanism for the two‐step process could be conf