Evaluation of furofuran as a P2 ligand f
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Xiaoqi Chen; Lin Li; Dale J. Kempf; Hing Sham; Norman E. Wideburg; Ayda Saldivar
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Article
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1996
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Elsevier Science
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English
β 313 KB
The hexahydrofurofuranyloxy group was evaluated as a conformationally constrained P2 ligand for symmetry-based HIV protease inhibitors. A number of compounds showed nM level activity against HIV in MT4 cells and lower protein binding than the licensed protease inhibitor ritonavir. However, replaceme