โ Scribed by Kenneth B. Saunders; Hari N. Bali; Ewert R. Carson
No coin nor oath required. For personal study only.
We have adapted the model of Grodins, Buell & Bart (1967) to include cyclic ventilation, dead space, shunt, and a separate muscle compartment.
(2) With a controller equation similar to that of Lloyd, Jukes & Cunningham (1958), governed by filtered values of arterial Pea, and Po" the model matched both steady state and dynamic results from man breathing increased CO 2 concentrations.
(3) With a technique using step inflow changes in CO 2 , we would predict steady-state ventilation to occur in three-four min, a potential experimental advantage.
(4) To maintain stability in simulated exercise at 100 W it was necessary: (i) to decrease shunt to a minimal value of 1% of cardiac output; (ii) to divert blood flow from other tissues to the muscle compartment; (iii) immediately to increase total blood flow to an appropriate physiological level, and to increase ventilation to that level required to maintain isocapnia in the steady state.
(5) Wrong dynamics obtained in the on-transients of exercise, and in breathing hypoxic mixtures, would be more appropriately corrected by adjusting the controller, rather than the controlled system (Saunders, 1980).
๐ SIMILAR VOLUMES
## Abstract This paper is concerned with computational modeling of the respiratory system against the background of acute lung diseases and mechanical ventilation. Conceptually, we divide the lung into two major subsystems, namely the conducting airways and the respiratory zone represented by lung
This paper is the first in a series devoted to the metrological evaluation of the interrupter technique (IT). The aim of it is to propose effective modification of the classical algorithm and to summarize the research concentrated on evaluating the usefulness of the pressure and flow data frequency