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A Biochemical Logic Gate Using an Enzyme and Its Inhibitor. 1. The Inhibitor as Switching Element

โœ Scribed by Sarit Sivan; Noah Lotan


Book ID
109388263
Publisher
American Institute of Chemical Engineers
Year
1999
Tongue
English
Weight
139 KB
Volume
15
Category
Article
ISSN
8756-7938

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## Abstract The enzyme specificity and tissue distribution of zenarestat, an aldose reductase inhibitor, was investigated in diabetic rats. Zenarestat inhibited both rat sciatic nerve aldose reductase (AR) activity and recombinant human AR with IC~50~ values of 7.5 and 44 nM, respectively. However,