sured values for DNA chains (of 367, 762, 1010, 2311 base pairs) shows excellent agreement as well. This lends confidence to the A carefully parameterized and tested simulation procedure for predictive ability of our model and sets the groundwork for further studying the dynamic properties of long l
A bead and spring model for the stiffness of DNA
✍ Scribed by J. García De La Torre; Juan J. Freire; Arturo Horta
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1975
- Tongue
- English
- Weight
- 443 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0006-3525
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The chain stiffness of linear native DNA is represented by a generalized bead and spring model recently proposed. It incorporates molecular rigidity by means of springs between beads, which are second neighbors along the contour of the chain. These springs are equivalent to elastic forces having longitudinal and transversal contributions. The model is compared with existing experimental data of sedimentation and low‐angle light scattering to obtain the statistical parameters of DNA. The value of the statistical length obtained with this model is 1300 Å. The same value is obtained with the wormlike chain. Throughout this analysis, excluded volume is left out as a simplifying assumption.
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Parts of this work are supported by the "Deutsche Forschungsgemeinschaft" (DFG -German Research Foundation) within the framework of the collaborative research centre 599 (SFB 599) "Sustainable bioabsorbable and permanent implants of metallic and ceramic materials". The authors are grateful for the s
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