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A Bait and Switch Hapten Strategy Generates Catalytic Antibodies for Phosphodiester Hydrolysis

โœ Scribed by Paul Wentworth, Yunqi Liu, Anita D. Wentworth, Ping Fan, Matthew J. Foley and Kim D. Janda

Book ID
123641377
Publisher
National Academy of Sciences
Year
1998
Tongue
English
Weight
849 KB
Volume
95
Category
Article
ISSN
0027-8424

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Esterolytic abzymes were generated via immunization with a haptenic diphosphonate mounted with two distinct traps actuated by the "bait and switch" and "transition-state mimic" concepts. One monoclonal antibody, 12F12, was characterized in detail, and showed significant rate enhancement and unique s