To isolate a putative tumor suppressor gene(+ we have constructed a physical map and a detailed deletion map of chromosome region 8p2 I .3-p22, where loss of heterozygosity (LOH) has been frequently seen in human hepatocellular carcinomas (HCC), colorectal cancers (CRC), and non-small cell lung canc
A 3p deletion in small cell lung carcinoma
β Scribed by William H. Falor; Rose Ward-Skinner; Scott Wegryn
- Book ID
- 119102924
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 153 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0165-4608
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Several somatic genetic alterations have been described in non-small-cell lung carcinomas (NSCLC). Recurrent chromosomal deletions have suggested the presence of tumor-suppressor genes specifically involved in lung carcinogenesis. For one of these, 2 non-overlapping regions have been proposed on the
We have used 14 DNA probes, which detect 19 different restriction enzyme length polymorphisms, t o search for heterozygosity on chromosome 3 in five cell lines isolated from patients with small cell lung carcinoma. The cell lines on karyotype analysis did not show the deletion in chromosome 3 charac