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A 1H-NMR determination of the solution structure of the A-chain of insulin: comparison with the crystal structure and an examination of the role of solvent

✍ Scribed by Bernadette L. Hawkins; Keith J. Cross; David J. Craik


Book ID
113269476
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
444 KB
Volume
1209
Category
Article
ISSN
0167-4838

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The Solution Structure of TRHβ€”A 1H NMR R
✍ T. Kanthimathi; L. Hughes; S. Subramanian πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 458 KB πŸ‘ 2 views

High-resolution 'H NMR and molecular mechanics calculations were used to evaluate the solution structure of TRH (pyroglutamic acid-histidine-prolinamide). The results indicate that there are only two rotamers present at room temperature with a sufficient energy barrier on the 400 MHz NMR time-scale