A 1:2 co-crystal of isonicotinamide and propionic acid
✍ Scribed by Oswald, Iain D. H. ;Motherwell, W. D. Sam ;Parsons, Simon
- Publisher
- International Union of Crystallography
- Year
- 2004
- Tongue
- English
- Weight
- 647 KB
- Volume
- 60
- Category
- Article
- ISSN
- 1600-5368
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An alternative and cost effective route for the resolution in high ees (95-99%) of (:-~)-mandelicand (.+-)-2-(chlorophenoxy)propionic-acid derivatives is reported. The key step involves the covalent derivatization and separation of their diastereomeric amides with (R)-or (S)-cC-arylethylamines.
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