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Resolution of (±)-mandelic- and (±)-2-(chlorophenoxy)propionic-acid derivatives by crystallization of their diastereomeric amides with (R)- or (S)-α-arylethylamines

✍ Scribed by Franck Jourdain; Takahiko Hirokawa; Tamizo Kogane

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 265 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)00258-0

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✦ Synopsis

An alternative and cost effective route for the resolution in high ees (95-99%) of (+)-mandelicand (-+)-2-(chlorophenoxy)propionic-acid derivatives is reported. The key step involves the covalent derivatization and separation of their diastereomeric amides with (R)-or (S)-c~-arylethylamines.

📜 SIMILAR VOLUMES

Resolution of (±)-mandelic- and (±)-2-(c

Resolution of (±)-mandelic- and (±)-2-(chlorophenoxy)propionic- acid derivatives by crystallization of their diastereomeric amides with (R)- or (S)-α-arylethylamines

✍ Franck Jourdain; Takahiko Hirokawa; Tamizo Kogane 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 257 KB

An alternative and cost effective route for the resolution in high ees (95-99%) of (:-~)-mandelicand (.+-)-2-(chlorophenoxy)propionic-acid derivatives is reported. The key step involves the covalent derivatization and separation of their diastereomeric amides with (R)-or (S)-cC-arylethylamines.