Hodgkin's disease biology: recent advanc
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Andrea Jox; JΓΌrgen Wolf; Volker Diehl
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Article
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1997
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John Wiley and Sons
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English
β 130 KB
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The cellular origin of H-RS cells has been questioned for a long time. Recently, using single cell amplification of Ig genes evidence was obtained that H-RS cells clonally arise from B-cells. Sequence analysis of rearranged Ig genes demonstrated that H-RS cells develop within the germinal centre. H-