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970 Increased gap junctional intercellular communication in esophageal cancer augments the bystander effect in HSV-tk/GCV suicide gene therapy

โœ Scribed by S. Matono; T. Tanaka; S. Sueyoshi; H. Sasahara; H. Yamana; H. Fujita; K. Shirouzu

Book ID
118621136
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
172 KB
Volume
1
Category
Article
ISSN
1359-6349

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Stimulation of intercellular communication of poor-communicating cells by gap-junction-competent cells enhances the HSV-TK/GCV bystander effect in vitro
โœ Toshiaki Tanaka; Hiroshi Yamasaki; Marc Mesnil ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 159 KB ๐Ÿ‘ 1 views

We have previously shown that gap-junctional intercellular communication (GJIC) appears to play a role in the bystander effect that is observed in anticancer suicide gene therapy mediated by herpes simplex virus (HSV) thymidine kinase (tk) and ganciclovir (GCV). We now report that when connexin-expr