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942 TYROSINE KINASE INHIBITOR SORAFENIB INDUCES GROWTH INHIBITION AND APOPTOSIS OF HUMAN PROSTATE CANCER CELLS BY REGULATION OF CELL CYCLE AND CELL DEATH CONTROLLING PROTEINS AND BLOCKING OF THE AKT PATHWAY

✍ Scribed by S.J. Oh; F.R. Santer; H. Erb; I.T. Cavarretta; A. Hobisch; Z. Culig

Book ID: 119623275
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 197 KB
Volume: 10
Category: Article
ISSN: 1569-9056
DOI: 10.1016/s1569-9056(11)60924-x

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## Abstract The epidermal growth factor (EGF) plays a role in the development of prostate cancer, which becomes essential after androgen resistance has emerged. The EGF receptor (EGFR) is therefore a potential target for anticancer therapy. We evaluated the effects of ZD1839 (‘Iressa’), an orally a