941 The Correlation Between SNP of IL28B and Mutations in the ISDR of NS5A of HCV 1A, 1b, 2A, 2B, 3a and the Response to Pegylated-Interferon-Alpha 2B and Ribavirin Combination Therapy
โ Scribed by Hayashi, Kazuhiko; Katano, Yoshiaki; Kuzuya, Teiji; Honda, Takashi; Tachi, Yoshihiko; Ishigami, Masatoshi; Goto, Hidemi
- Book ID
- 122104135
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 178 KB
- Volume
- 142
- Category
- Article
- ISSN
- 0016-5085
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## Abstract Genetic polymorphisms of the interleukin 28B (IL28B) locus are associated closely with outcomes of pegylatedโinterferon (PEGโIFN) plus ribavirin (RBV) combination therapy. The aim of this study was to investigate the relationship between IL28B polymorphism and responses to therapy in pa
## Abstract Hepatitis C virus (HCV) genotype 1a is rare in Japanese patients and the clinical characteristics of this genotype remain unclear. The interferon (IFN) sensitivityโdetermining region (ISDR) and singleโnucleotide polymorphisms (SNPs) of interleukinโ28B (IL28B) among patients with HCV gen