## Abstract The cβ__erb__ Bβ2/__neu__ gene encodes a cellβsurface glycoprotein with extensive homology to, but distinct from, the epidermal growthβfactor receptor. In this study, we compared the cβ__erb__ Bβ2/__neu__ gene amplification and expression of tissue specimens obtained from the bladders o
91 Studies on the organization and expression of proto-oncogenes c-erb B1 and c-erb B2 in primary human breast carcinomas
β Scribed by I. Meybohm; S. Singh; K. Friedrichs; W. Jonat; H. Maass; H.W. Goedde
- Book ID
- 119104481
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 91 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Both amplification and overexpression of cβ__erb__ Bβ2/__neu__ have been associated with the progression and possible prognosis of a number of human cancers. In this study, we demonstrated that cβ__erb__ Bβ2/__neu__ may also play an important role in human prostate cancer. Our conclusio
Expression of oncogenes in gastric cancer tissue was evaluated with immunohistochemical staining methods using monoclonal antibodies to products of the oncogenes. Rates of expression in gastric cancer tissue were 50% for c-myc, 72% for c-erb B,, and 56% for c-Ha-rus oncogenes. Expression of these on
The c-met and the c-erb B-2 protooncogenes belong to a family of tyrosine kinase growth factor receptors. Abnormalities of these oncogenes and protein products have been reported in several cancers. The authors investigated the correlation between clinical factors and amplification or overexpression