9-pyridylidenefluorenes, a new class of anti-inflammatory substances

✍ Scribed by N. P. Buu-Hoï; F. Delbarre; P. Jacquignon; H. Brouilhet; A. Rose; J. F. Sabathier; M. P. Sinh

• Book ID: 104586700
• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 163 KB
• Volume: 82
• Category: Article
• ISSN: 0165-0513
• DOI: 10.1002/recl.19630821102

✦ Synopsis

Abstract

The condensation of fluorene with the three formylpyridines and 2‐formyl‐6‐methylpyridine has been investigated, and the 9‐pyridylidenefluorenes obtained have been tested in rats for anti‐inflammatory activity. 9‐(3‐Pyridylidene)fluorene proved the most potent compound, with an activity half of that of subcutaneously injected prednisone, in an oral dose ten times greater.