9-oxo-6-oxa-1-azabicyclo[5.2.0]non-4-enes, by-products arising in the total synthesis of clavulanic acid analogues
β Scribed by Peter H. Bentley; Gerald Brooks; Martin L. Gilpin; Eric Hunt; Iskander I. Zomaya
- Book ID
- 108384723
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- French
- Weight
- 124 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0040-4039
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## Abstract Ethyl 4βoxoalkanoates 1 react at ambient temperature in dry methanol in the presence of molecular sieve 3 Γ in almost quantitative yield with 3βaminopropanol and 2βaminoethanol to form the bicyclic lactams __rac__β2 and __rac__β3, respectively. Surprisingly, the (Β±)β5βalkylβ4βoxaβ1βazab