9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα
✍ Scribed by Levin, Arthur A.; Sturzenbecker, Laurie J.; Kazmer, Sonja; Bosakowski, Thomas; Huselton, Christine; Allenby, Gary; Speck, Jeffrey; ratzeisen, Cl.; Rosenberger, Michael; Lovey, Allen
- Book ID
- 109779456
- Publisher
- Nature Publishing Group
- Year
- 1992
- Tongue
- English
- Weight
- 366 KB
- Volume
- 355
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/355359a0
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Mouse F9 embryonic teratocarcinoma stem cells can be induced to differentiate into visceral endoderm. Following retinoic acid (RA) treatment, alpha-fetoprotein (AFP), a differentiation marker, is expressed and secreted. The mechanism by which RA regulates AFP expression during differentiation is not