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9-cis-retinoic acid: A direct-acting dysmorphogen

✍ Scribed by Joan Creech Kraft; Mont R. Juchau

Book ID
115783542
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
794 KB
Volume
46
Category
Article
ISSN
0006-2952

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9-cis-Retinoic acid (9-cis-RA) is a stereo-and photoisomer of all-nuns-retinoic acid (all-nuns-RA) [l]. The cancer chemopreventive activities of the all-trans and 1 3 4 s (13-cis-RA) isomers of retinoic acid [2] are well recognized. The biological effects of retinoids are mediated by intracellular r

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✍ Youssef L. Bennani 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 430 KB

## Abstract 1‐[^13^CD~3~]‐9‐__cis__‐Retinoic acid was prepared in 8 steps from 2,6‐dimethylcyclohexanone. Alkylation of 2,6‐dimethylcyclohexanone under LiHMDS/MnBr~2~/^13^CD~3~I gave the corresponding labeled 2‐[^13^CD~3~]‐2,2,6‐trimethylcyclohexanone 4 in good yield. Further functionalization of 4