1-(2'-Deoxy-~-o-fhreo-pentofuranosyl)thymine ( = l-(2'-deoxy-~-~-xylofuranosyl)thymine; xT,; 2 ) was converted into its phosphonate 3b as well as its 2-cyanoethyl phosphoramidite 3c. Both compounds were used for solid-phase synthesis of d[(xT),,-TI (5), representing the first DNA fragment build up f
9-(2′-Deoxy-β-D-xylofuranosyl)adenine Building Blocks for Solid-Phase Synthesis and Properties of Oligo(2′-deoxy-xylonucleotides)
✍ Scribed by Helmut Roscmeycr; Marcela Krečmerova; Frank Seela
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- German
- Weight
- 877 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0018-019X
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The syntheses of 7-deaza-N6-methyladenine N9-(2'-deoxy-~-o-ribofuranoside) (2) as well as o f 8-aza-7-deaza-N6-methyladenine N8-and N9-(2'-deoxyribofuranosides) (3 and 4, resp.) are described. A 4,4'-dimethoxytritylation followed by phosphitylation yielded the methyl phosphoramidites 12-14. They wer