891 TP53 binding protein-1 and mutated in Ataxia-Telangiectasia gene variants affect TP53 mutations in lung cancer
β Scribed by S. Zienolddiny; V. Skaug; A. Haugen
- Book ID
- 119602665
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 36 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1359-6349
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Which carcinogens are of influence in the development of human colorectal cancers remains a question; one answer could be the finding that specific polymorphisms in xenobiotic metabolizing enzymes are related to particular mutations in cancer genes. __KRAS2__ and __TP53__ gene mutations
The functional consequences of missense variants are often difficult to predict. This becomes especially relevant when DNA sequence changes are used to determine a diagnosis or prognosis. To analyze the consequences of 12 missense variants in patients with mild forms of ataxia-telangiectasia (A-T),