873 A MIXTURE OF NATIVE AND RECOMBINANT MITOCHONDRIAL ANTIGENS IMPROVES THE DETECTION OF PRIMARY BILIARY CIRRHOSIS-SPECIFIC ANTIBODIES
β Scribed by C. Daehnrich; M. Mytilinaiou; A. Rosemann; C. Probst; W. Schlumberger; D. Bogdanos; W. Stoecker; L. Komorowski
- Book ID
- 117376799
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 58 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0168-8278
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The appearance of autoantibodies against mitochondria in patients with primary biliary cirrhosis has been known for more than 25 yr. In the past, based on the biochemical complexity of the mitochondrion and the use of crude extracts for immunodiagnosis, a degree of nonspecificity in assaying for ant
## HEPATOLOW Copvright (0 19fk5 by the American A s ~x i a t i o n Iiir the Study of Liver Diseases
Studies with subfractions of Saccharornyces cerevisiae obtained by differential centrifugation showed only two primary biliary cirrhosis-specific antigens. These antigenic species were shown, using preabsorption studies, to have determinants cross-reactive with their mammalian counterpart. Distribu