Anti-tumor necrosis factor β£ (TNF-β£) treatment decreases nitric oxide (NO) synthesis and ameliorates the hyperdynamic circulation in portal hypertensive rats. We have recently demonstrated that nitric oxide synthase isoform 3 (NOS3) is overexpressed in portal hypertensive gastric mucosa and that res
86 Role of tumor necrosis factor and nitric oxide in portal hypertension
β Scribed by Nicholas J. Skill; Nicholas G. Heodorakis; Yining N. Wang; Matthew M. Metz; Eileen M. Redmond; James V. Sitzmann
- Book ID
- 119529995
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 127 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0270-9139
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π SIMILAR VOLUMES
Portal hypertension accompanied by anatomic or served in portal hypertension with liver failure or extenfunctional portal-systemic shunting very often is assosive portal-systemic shunting. Tumor necrosis factor a ciated with a hyperdynamic circulatory state. The so-(TNF) causes marked hypotension in
Systemic and especially splanchnic arterial vasodilation accompany chronic portal hypertension. Different soluble mediators causing this vasodilation have been proposed, the strongest evidence being for nitric oxide (NO). No data exist if structural vascular changes may partly account for this vasod