8574 A phase II study of combination chemotherapy with capecitabine and cisplatin in patients with metastatic or recurrent head and neck cancer
โ Scribed by Won, Y.W.; Park, Y.H.; Ahn, M.J.; Park, K.
- Book ID
- 122466320
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 45 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1359-6349
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## Abstract ## Background. The aims of this study were to determine the recommended dose (RD) in combination chemotherapy of Sโ1 and carboplatin in recurrent and/or metastatic head and neck cancer (phase I) and to examine response rate and toxicities at RD (phase II). ## Methods. Sโ1 was given o
Thirty patients with recurrent and/or metastatic head and neck cancer were treated with sequentially administered methotrexate (MTX) and piritrexim (PTX). The treatment schedule consisted of intravenous (IV) MTX (50 mg/m') administered on day 1 and oral PTX (75 mg/mz) administered twice daily on day