The International Gastric Cancer Linkage Consortium (IGCLC) predicted that up to 25% of families fulfilling the criteria for hereditary diffuse gastric cancer (HDGC) would harbor CDH1 germline mutations. This was based on observations from the low number of diffuse gastric cancer families described
β¦ LIBER β¦
821 Analysis of Germline E-cadherin Mutations in Brazilian Patients With Hereditary Diffuse Gastric Cancer
β Scribed by K.S. Alfradique; M.A. Ferreira; C.G. Stefanoff
- Book ID
- 117663287
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 72 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0959-8049
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## Abstract Somatic mutations in the __Eβcadherin__ (__CDH1__) gene have frequently been reported in cases with diffuse gastric and lobular breast cancers. Recently, germline mutations have been identified in families with diffuse gastric cancers. In families with hereditary prostate cancer (HPC),