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82 Reduced breast cancer metastasis in plasminogen-deficient mice

✍ Scribed by Thomas H. Bugge; Leif R. Lund; Keith K. Kombrinck; Bøje S. Nielsen; Keen Holmbäck; Angela F. Drew; Matthew J. Flick; David P. Witte; Keld Danø; Jay L. Degen


Book ID
117439460
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
132 KB
Volume
11
Category
Article
ISSN
0268-9499

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A prominent phenotype of plasmin deficiency in mice is reduced metastasis in the MMTV-PymT transgenic breast cancer model. Proteolytically active plasmin is generated from inactive plasminogen by one of 2 activators, uPA or tPA. We now find that uPA deficiency alone significantly reduces metastasis