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807-5 Extracellular pH modifies drug blockade on the human ether-A-go-go related gene (HERG) channels

✍ Scribed by Lin Congrong; Ivana Cvetanovic; Vasant Ranade; John C Somberg

Book ID: 119548323
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 92 KB
Volume: 43
Category: Article
ISSN: 1558-3597
DOI: 10.1016/s0735-1097(04)90512-8

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## Abstract It is presumed that phosphodiesterase (PDE) inhibitors have two mechanisms for inhibition of hERG currents in the acute applications to cells: direct channel block, and downregulation of human ether‐a‐go‐go related gene (hERG) activities by PKA‐dependent pathway mediated phosphorylation