8009 Human papillomavirus type16 (HPV16) E6 gene variations in cervical intraepithelial lesion from Thai women
β Scribed by Chaiwongkot, A.; Pientong, I.; Ekalaksananan, T.; Kongyingyoes, B.; Siriaungkul, S.; Suthippintawong, C.; Vinyuvat, S.; Tungsinmunkong, K.; Triratanachat, S.; Chuangsuwanich, T.
- Book ID
- 122444925
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 67 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1359-6349
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## Abstract By a combination of reversed transcription and subsequent polymerase chain reaction (RNAβPCR), 23 cytologically normal cervical scrapings, positive for the presence of human papillomavirus type 16 (HPV 16) DNA, were analyzed for the presence of transcripts originating from the E6 region
We microdissected 15 specimens of invasive cervical cancer co-existing with some of its precursors. Out of 15 cases, 10 carried HPV16, 2 HPV31, 1 HPV18 and 2 were HPVnegative. We found 3 HPV16 E6 variants among the 10 cases; one was A = = G in nt 131 (one case) and a second was A = = G in nt 276. Th